Symptoms of Alpha-1

• Considering Alpha-1 Testing
• Newly Diagnosed with Alpha-1
• Living With Alpha-1

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The following symptoms and conditions may be indications of alpha-1 antitrypsin (AAT) deficiency.¹

• Early onset of emphysema (age 45 years or less)
• COPD – emphysema, chronic bronchitis or bronchiectasis
• Family history of any of the following: emphysema/COPD, liver disease or panniculitis
• Asthma with minimal response to medication, inhalers
• Shortness of breath with routine activity
• Cough with or without mucus
• Wheezing
• Liver disease with unknown cause

If you are concerned, ask your doctor if you should be tested for AAT deficiency. For more information about testing, visit the Testing for Alpha-1 section. You may also download a printable version of Should You Be Tested? to share with friends and family you may be concerned about.

1. Adapted from the American Thoracic Society/European Respiratory Society Statement. Standards for the diagnosis and management of individuals with AAT deficiency. Am J Respir Crit Care Med. 2003;168:818-900.